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Genetic model offers elegant tool for testing Parkinson’s disease therapies

For the past decade, Parkinson's disease researchers have relied on the experimental equivalent of using a sledgehammer to tune a guitar to test new therapies for the disease. This may be a reason clinical trials of promising neuroprotective drugs fail. But, in new research published today in Nature Parkinson's Disease, University of British Columbia researchers may have found the ideal tool for the job.

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Preparing for chemical attacks with improved computer models

Researchers have used computer models on the Stampede2 supercomputer to replicate the dispersal of gases from the April 4, 2017 chemical weapons attack in northwest Syria. The simulations were able to capture real world conditions despite a scarcity of information. Recently, the team developed a coarse model that uses seasonal conditions as background information to speed up calculations, reducing forecasting time from days to minutes.

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Lower-risk malaria regions are breeding grounds for drug-resistant strains

New drug-resistant strains of the parasite that causes malaria tend to evolve in regions with lower malaria risk; in areas with high transmission rates, they get outcompeted by the more common, drug-sensitive strains inside the human host. In high-transmission settings, it takes a long time for drug-resistant strains to take hold, but once they do, they can spread rapidly, according to a new study.

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